- Author:
- Weiwei Ai <wai484@aucklanduni.ac.nz>
- Date:
- 2024-04-24 10:15:46+12:00
- Desc:
- Correct the direction of ss flux; update the fast parameters (so the solver can handle)
- Permanent Source URI:
- http://models.cellml.org/workspace/b65/rawfile/378f5bf1311102d61933906b9747d332a3ea69cf/Electrogenic cotransporter/params_BG_ss_2005B.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="params_BG" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="./units.cellml">
<units name="per_fmol" units_ref="per_fmol"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="fmol_per_s" units_ref="fmol_per_s"/>
<units name="fmol" units_ref="fmol"/>
<units name="J_per_K_mol" units_ref="J_per_K_mol"/>
<units name="mM" units_ref="mM"/>
<units name="pL" units_ref="pL"/>
<units name="fA" units_ref="fA"/>
<units name="fF" units_ref="fF"/>
</import>
<component name="params_BG">
<variable initial_value="8.31" name="R" public_interface="out" units="J_per_K_mol"/>
<variable initial_value="293" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96485" name="F" public_interface="out" units="C_per_mol"/>
<variable initial_value="5.670e-08" name="K_Nai" public_interface="out" units="per_fmol"/>
<variable name="q_Nai" public_interface="out" units="fmol"/>
<variable initial_value="5.670e-08" name="K_Nao" public_interface="out" units="per_fmol"/>
<variable name="q_Nao" public_interface="out" units="fmol"/>
<variable initial_value="2.128e-06" name="K_Glci" public_interface="out" units="per_fmol"/>
<variable name="q_Glci" public_interface="out" units="fmol"/>
<variable initial_value="2.128e-06" name="K_Glco" public_interface="out" units="per_fmol"/>
<variable name="q_Glco" public_interface="out" units="fmol"/>
<variable initial_value="2.277" name="K_1" public_interface="out" units="per_fmol"/>
<variable initial_value="55.35259603675412" name="q_init_1" public_interface="out" units="fmol"/>
<variable initial_value="33.056" name="K_2" public_interface="out" units="per_fmol"/>
<variable initial_value="55.35259603675412" name="q_init_2" public_interface="out" units="fmol"/>
<variable initial_value="11.958" name="K_3" public_interface="out" units="per_fmol"/>
<variable initial_value="55.35259603675412" name="q_init_3" public_interface="out" units="fmol"/>
<variable initial_value="11.958" name="K_4" public_interface="out" units="per_fmol"/>
<variable initial_value="55.35259603675412" name="q_init_4" public_interface="out" units="fmol"/>
<variable initial_value="1.679" name="K_5" public_interface="out" units="per_fmol"/>
<variable initial_value="55.35259603675412" name="q_init_5" public_interface="out" units="fmol"/>
<variable initial_value="0.325" name="K_6" public_interface="out" units="per_fmol"/>
<variable initial_value="55.35259603675412" name="q_init_6" public_interface="out" units="fmol"/>
<variable name="V0_Vm" public_interface="out" units="volt"/>
<variable initial_value="0.3" name="z_zf1" public_interface="out" units="dimensionless"/>
<variable initial_value="0.3" name="z_zr1" public_interface="out" units="dimensionless"/>
<variable initial_value="0.7" name="z_zf6" public_interface="out" units="dimensionless"/>
<variable initial_value="0.7" name="z_zr6" public_interface="out" units="dimensionless"/>
<variable initial_value="15.126" name="kappa_r1" public_interface="out" units="fmol_per_s"/>
<variable initial_value="1.672" name="kappa_r2" public_interface="out" units="fmol_per_s"/>
<variable initial_value="4.181" name="kappa_r3" public_interface="out" units="fmol_per_s"/>
<variable initial_value="66.900" name="kappa_r4" public_interface="out" units="fmol_per_s"/>
<variable initial_value="5.956" name="kappa_r5" public_interface="out" units="fmol_per_s"/>
<variable initial_value="15.370" name="kappa_r6" public_interface="out" units="fmol_per_s"/>
<variable initial_value="9.076e-03" name="kappa_r7" public_interface="out" units="fmol_per_s"/>
<variable initial_value="10" name="Nai" units="mM"/>
<variable initial_value="100" name="Nao" units="mM"/>
<variable initial_value="1e-6" name="Glci" units="mM"/>
<variable initial_value="10" name="Glco" units="mM"/>
<variable initial_value="8.5e5" name="V_i" units="pL"/>
<variable initial_value="8.5e5" name="V_o" units="pL"/>
<variable name="t" public_interface="out" units="second"/>
<variable name="V_E" public_interface="out" units="volt"/>
<variable initial_value="-0.15" name="test_volt" units="volt"/>
<variable initial_value="-0.05" name="hold_volt" units="volt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V0_Vm</ci>
<ci>V_E</ci>
</apply>
<apply>
<eq/>
<ci>q_Nai</ci>
<apply>
<times/>
<ci>Nai</ci>
<ci>V_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Nao</ci>
<apply>
<times/>
<ci>Nao</ci>
<ci>V_o</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Glci</ci>
<apply>
<times/>
<ci>Glci</ci>
<ci>V_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>q_Glco</ci>
<apply>
<times/>
<ci>Glco</ci>
<ci>V_o</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_E</ci>
<piecewise>
<piece>
<ci>hold_volt</ci>
<apply>
<lt/>
<ci>t</ci>
<cn cellml:units="second" type="e-notation">1204.75<sep/>-3</cn>
</apply>
</piece>
<piece>
<ci>test_volt</ci>
<apply>
<lt/>
<ci>t</ci>
<cn cellml:units="second" type="e-notation">1984.75<sep/>-3</cn>
</apply>
</piece>
<otherwise>
<ci>hold_volt</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
</model>
